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DePuy Artificial Hip Recall: Is There A Cancer Risk?

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DePuy hip recall defect may cause cancerCritical information from Johnson & Johnson’s recall of its DePuy ASR hip replacement system has not been covered in most reports: The ASR hips recalled by DePuy can potentially release toxic, perhaps cancer-causing, metal shavings into the tissue surrounding the defective artificial hip and be spread throughout the body through the bloodstream.

The ASR XL Acetabular Head System and ASH Hip Resurfacing System were designed for metal-on-metal construction, which permits grinding and allows metal particles to enter the tissue surrounding the hip replacement site. When these metals — Cobalt and Chromium — enter the tissues and are spread to other areas of the body though the blood stream, can cause serious medical side effects.

Metal on Metal Hip Replacement May Cause Cancer

A May 2010 State of Alaska Epidemiology Bulletin noted Cobalt toxicity in hip replacement patients. According to the bulletin, 35% of the nearly 113,000 hip replacements from October 2005 through then end of 2006 were metal-on-metal hip replacements.

Cobalt and chromium ions are commonly detected in the blood and urine of MoMHA patients as a result of wear at the bearing surfaces over time. The accumulation of metal ions in the areas surrounding the prosthetic join can cause metallosis, indicated by the formation of giant cells and fibrosis in surrounding tissue.

Elevated Cobalt levels can cause serious side effects at elevated exposure levels. Symptoms of cobalt poisoning include:

  • Visual impairment
  • Cardiomyopathy
  • Cognitive Impairment
  • Auditory Impairment
  • Hypothyroidism
  • Peripheral Neuropathy
  • Rashes

The Alaska Bulletin noted at least three prior case reports of blindness, deafness, heart failure, and other serious side effects resulting from a defective metal-on-metal hip replacement.

Chromium — also found in the Johnson & Johnson recalled hip systems — is a cancer causing agent, though Chromium III is considered less toxic than Chromium VI (hexavalent chromium).

When the Cobalt and Chromium ions are released by the metal-on-metal grinding of the artificial hip, the metal contaminates surrounding tissues. As the contaminated tissue deteriorates over time, the metal particles enter the blood stream and are carried to other parts of the body. Prolonged exposure can cause toxicity and may cause cancer.

Patients who may have received a defective hip should get more information about the DePuy hip recall and potential dangers.

(c) Copyright 2010 Brett A. Emison

1 Comment

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  1. Jeff Blackwell says:
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    Great post! I had read the research you cited as well on cobalt toxicity and find the subject very interesting.